Some rules of thumb for performing skin biopsies.
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“Always take at least three biopsy samples, preferably 6-mm punches. Never submit one-punch biopsy; pathologists need more than that to allow proper diagnosis. Never biopsy the edge of a lesion unless the other samples submitted are from the center of lesions. Exception: ulcerative skin disease would be an example to perform a biopsy from the edge of a lesion. In cases of alopecia, biopsy in the worst areas of hair loss.”
-Carlo Vitale, DVM, DACVD
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