Credelio Quattro launches at VMX

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Lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets (Credelio Quattro; Elanco Animal Health) have officially been launched and are now available to order, according to a recent announcement by Elanco Animal Health (Elanco).¹ The product, which provides canine protection against 6 parasites, made its debut at the 2025 Veterinary Meeting & Expo (VMX) in Orlando, Florida.

The drug, which received FDA approval in October 2024, is the only monthly chewable tablet that offers protection against 6 different parasites, including 3 intestinal worms that can be transmitted to humans.^1,2 These include:

• Tapeworms
• Roundworms
• Hookworms (Uncinaria stenocephala)
• Heartworms
• Ticks
• Fleas

The combination chewable tablet is indicated for monthly administration and is suitable for dogs aged 8 weeks or older weighing 3.3 lb or more. It is also designed to offer prevention of heartworm disease.

“Today is a historic day as we bring veterinarians and pet owners peace of mind with the broadest parasite protection of its kind for dogs," Bobby Modi, executive vice president, US Pet Health and Global Digital Transformation, said in a company release.¹ “By providing the broadest range of parasite protection of its kind, covering 6 parasites in a single, chewable, Credelio Quattro delivers on pet owner expectations, while strengthening Elanco's market presence and positioning us for continued growth in the parasiticide segment,” he continued.

According to a survey by Elanco, 94% of dog owners consider proactive treatment for intestinal worms to be a top priority. When choosing protection for their dogs, owners value effectiveness, parasite coverage, and length of protection the most, according to the company.¹

The survey also revealed that only 1 in 3 participants recognized that fleas and ticks pose a year-round risk. Additionally, half of the dog owners surveyed protect their dog from heartworm disease throughout the year.¹

"Parasites like tapeworms, fleas, and ticks can carry dangerous diseases and some of these can spread from dogs to humans," Casey Locklear, DVM, parasiticide lead for Elanco Animal Health said in the release.¹ "The Companion Animal Parasite Council (CAPC) recommends year round prevention of parasites, even during the winter months and specifically mentions the need for monthly deworming of dogs with praziquantel in areas where a certain type of tapeworm—E. granulosus tapeworms—are endemic."

“Credelio Quattro has incredibly broad spectrum against fleas and ticks because of the lotilaner component; tapeworms with the praziquantel; hookworms and roundworms with the pyrantel; and then heartworm prevention with moxidectin,” said Susan E. Little, DVM, PhD, DACVM, Krull-Ewing professor of parasitology at the Center for Veterinary Health Sciences at Oklahoma State University in Stillwater, in an interview with dvm360. “So it [offers] a broad spectrum protection against a wide variety of parasites that dogs are going to encounter on a regular basis, and so we really need to make sure they’re protected.”

Credelio Quattro should be used with caution in dogs with a history of seizures or neurological disorders.¹ Additionally, dogs should be tested for heartworm infections prior to Credelio Quattro administration, as it does not work against adult heartworm D immitis.¹

The products safety in breeding, pregnant, or lactating dogs has not been evaluated. Vomiting and diarrhea were the most commonly reported adverse reactions during clinical trials.¹ Complete safety information can be found on the Credelio Quattro product label.

References

1. Now available: Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) provides broadest[i] parasite protection of its kind. News release. Elanco Animal Health. January 23, 2025. Accessed January 28, 2025. https://prnmedia.prnewswire.com/news-releases/now-available-credelio-quattro-lotilaner-moxidectin-praziquantel-and-pyrantel-chewable-tablets-provides-broadesti-parasite-protection-of-its-kind-302357947.html
2. Bautista-Alejandre A. FDA approves oral drug for broad canine protection against parasites. dvm360. October 7, 2024. Accessed January 28, 2025. https://www.dvm360.com/view/fda-approves-oral-drug-for-broad-canine-protection-against-parasites