First generic drug for pruritus and cough conditions in dogs to be exhibited at VMX
The antihistamine and corticosteroid Trimeprazine with Prednisolone Tablets received FDA approval last year
Photo: kasto/Adobe Stock
Trimeprazine with Prednisolone Tablets, the generic equivalent of Temaril-P (Zoetis), will be displayed at this year’s Veterinary Meeting & Expo’s (VMX) New Product Showcase exhibit by manufacturer Zyvet Animal Health. The product is the first generic trimeprazine with prednisolone tablets for dogs.1
The generic drug is recommended for itch relief in dogs. This antihistamine and corticosteroid is also indicated for adjunctive treatment for various canine cough conditions such as tracheobronchitis, also known as ‘kennel cough’; bronchitis, including all allergic bronchitis; and infections and coughs of unknown cause.2 It can also lower inflammation related to most skin disorders of dogs, such as eczema caused by internal disorders, otitis, and dermatitis. It is often effective in relieving pruritic that does not respond to other treatments.3
Zyvet's drug received FDA approval on June 20, 2024 as an antipruritic and antitussive therapy for dogs. It is only available by prescription in bottles of 100 or 1000 tablets. Each tablet contains 5 mg of trimeprazine as trimeprazine tartrate and 2 mg of prednisolone. The starting dose is based on the patient’s weight4:
- For dogs up to 10 lb: ½ tablet twice daily
- For dogs weighing 11-20 lb: 1 tablet twice daily
- For dogs weighing 21-40 lb: 2 tablets twice daily
- For dogs over 40 lb: 3 tablets twice daily
After 4 days of treatment, the dosage is decreased to half of the starting dose or adjusted to the minimum amount needed to maintain remission of symptoms, according to the American Veterinary Medical Association.4
“Less than 20% of the animal health market offers a generic to pioneer products. ZyVet leverages its parent company’s 70-year legacy in pharmaceutical excellence to challenge the status quo,” wrote ZyVet in a company release.1 “By delivering affordable, high-quality generics, ZyVet empowers veterinarians to provide exceptional care, enhancing the human-animal bond at affordable pricing.”
“We're here to disrupt and change the conversation about generics and reinforce that quality and innovation can go hand-in-hand,” Lauren Landolph, head of commerical for ZyVet, said in the release.1 "The launch of Trimeprazine with Prednisolone Tablets, along with the full portfolio lineup, exemplifies our commitment to deliver effective and affordable solutions that meet the needs of today’s veterinary clinics.”
Trimeprazine with Prednisolone should not be used in animals with Cushing syndrome. Veterinary professionals should exercise caution when using in pregnant animals owing to risks of premature parturition or congenital anomalies. Adverse effects associated with corticosteroid use include delayed wound healing, vomiting, and bacterial infections.1
Veterinarians can learn about more about ZyVet’s product lineup at VMX. The event will take place January 25-29 in Orlando, Florida.
References
- ZyVet Animal Health brings affordable innovations to the veterinary profession. News release. ZyVet Animal Health. January 21, 2025.
- FDA roundup: June 21, 2024. News release. US Food & Drug Administration. June 21, 2024. Accessed January 22, 2025. https://www.fda.gov/news-events/press-announcements/fda-roundup-june-21-2024
- Freedom of Information Summary. US Food & Drug Administration. June 20, 2024. Accessed January 22, 2025. https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/15546
- FDA approves first generic drug for hyperthyroidism in cats. American Veterinary Medical Association. August 6, 2024. Accessed January 22, 2025. https://www.avma.org/news/fda-approves-first-generic-drug-hyperthyroidism-cats#:~:text=On%20June%2020%2C%20the%20FDA,drug%20product%2C%20Temaril%2DP.
