Potential breakthrough in periodontal disease treatment gel

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Oral Biolife (OBL), a biotechnology company currently developing a first-of-its-kind dental treatment for both humans and companion animals, announced a new development of data in support of their flagship product: Ambrilux Dental Gel.¹ Recent studies have proven the product to be effective in promoting the regeneration of bone in the furcations of teeth in 3 beagles that were induced with periodontal disease (PD).¹

“This proof-of-concept marks a major milestone in our journey. It reinforces our confidence that Ambrilux Dental Gel has the potential to revolutionize how dental care is provided, offering a less invasive and more accessible option for patients,” Bill Breitenbach, CEO of Oral Biolife, said in a news release.¹

In the study, radiographs were taken at baseline 28 days following the first application of the product, and 29 days after the second application. Results of the radiographs demonstrated that all 3 dogs that were treated with the product showed an increase in bone regeneration at both the first- and second-months post-treatment.¹ Meanwhile, just 1 out of 3 control animals demonstrated detectable bone growth. Furthermore, there were no adverse events or other safety hazards noted during the study.¹

In July 2024, Oral Biolife announced that they’d formed a strategic partnership with a “top-tier global leader in animal health,” to develop a product intended to revolutionize the way PD is treated in companion animals.²

“OBL is utilizing advanced biotechnology to create a revolutionary approach to combat and treat [PD], which will enhance the overall wellness and health of animals,” Breitenbach said of the partnership in a July news release.² “This partnership is a significant step forward to opening a gateway for veterinarians to access a treatment solution for PD, while simultaneously spreading awareness of oral health in animals.”

It's the unfortunate truth that most dogs—80 to 90% over the age of 2—have some component of periodontal disease.³ These numbers are even worse in smaller dogs, and the incidence increases along with age.³ Dogs with periodontal disease will likely show signs of pain by pawing or rubbing at their mouths, drooling, a decreased appetite or other changes in eating habits, blood or odor from the mouth, along with behavioral changes.³ For the best chance at preventing periodontal disease, regular veterinary dental cleanings, in addition to proper home dental care, are recommended.³

“At OBL our mission has always been to find a way to provide Americans with access to non-invasive dental care,” Stella Vnook, president of Oral Biolife, said.¹ “We are pleased with these promising results and are excited to continue our research to further establish the safety and efficacy of the Ambrilux Dental Gel.”

References

1. Oral Biolife Announces Large Animal Data Breakthrough in Periodontal Disease. News release. Oral Biolife. October 8, 2024. Accessed October 10, 2024. https://world.einnews.com/pr_news/749770634/oral-biolife-announces-large-animal-data-breakthrough-in-periodontal-disease
2. Oral Biolife Inc. Announces Animal Health Partnership to Support Animal Oral Health. News release. Oral Biolife. July 31, 2024. Accessed October 10, 2024. https://world.einnews.com/pr_news/731942189/oral-biolife-inc-announces-animal-health-partnership-to-support-animal-oral-health
3. Periodontal disease. Cornell University College of Veterinary Medicine. Accessed October 10, 2024. https://www.vet.cornell.edu/departments-centers-and-institutes/riney-canine-health-center/canine-health-information/periodontal-disease