Dennis DeNicola, DVM, PhD, DAVCP

Advancements in hematology have aided veterinarians greatly. Today's equipment for inclinic hematology analysis can provide accurate white blood cell (WBC) counts and partial or complete differential leukocyte counts. When considering leukocyte differentials, practitioners may ask whether a five-part differential is necessary. In a word, yes. To interpret leukocyte changes in a patient accurately, practitioners must obtain a WBC count and a complete fivepart differential. They should also obtain a peripheral blood film to assess the leukocytes for any morphologic changes. In some cases, practitioners may need to do serial complete blood counts (CBCs) to understand the changes in the different leukocyte forms during various disease states.