Two organizations partner to develop research on veterinary device for osteoarthitis

X-ray of a dog with Osteoarthritis in the elbow

Photo: Henk Vrieselaar/Adobe Stock

PetVivo Holdings, Inc—a biomedical company of therapeutic medical devices for equines and pets—announced a new partnership with Orthobiologic Innovations (OBI)—a research and development company for regenerative and sports medicine. The collaboration will help PetVivo pursue new clinical trials of its medical device for animals with osteoarthritis: Spryng with OsteoCushion Technology. The partnership will also allow the company to market and further develop its product, according to a news release.¹

Osteoarthritis is a condition characterized by the gradual breakdown of articular cartilage in diarthrodial joints, according to Merck Veterinary Manual.² This breakdown leads to thinning of the hyaline cartilage, joint effusion, and periarticular osteophyte formation.² This disease may result from trauma, infections, immune-related disorders, or developmental malformations. Moreover, symptoms of degenerative joint disease can include lameness, joint swelling, muscle wasting, fibrosis around the joint capsule, and crepitus.²

Spryng with OsteoCushion Technology is an intra-articular injectable veterinary device that addresses the missing and damaged cartilage in joints associated with lameness issues. The injection works by forming a shock-absorbing matrix that works with synovial fluid to replicate the protective structure and function of healthy, natural joint cartilage, according to the product website.³

This microparticulate is characterized by its lubricating and viscoelastic qualities. According to PetVivo Inc, microparticles in the injection are created from collagen and elastin, along with a carbohydrate. The combination of collagen, elastin, and the carbohydrate create a strong and hydrated material that closely resembles the properties of natural cartilage.³

OBI will first help PetVivo organize several Spryng clinical trials focused on managing joint issues in the elbows and stifle of canine patients, according to the release.¹ These initial studies will evaluate the injection of collagen-elastin hydrogel microparticles into the elbows of dogs with osteoarthritis and into the stifles of dogs that have had a tibial plateau leveling osteotomy (TPLO) procedure. Moreover, OBI will support other studies planned for next year.

“As a double-boarded orthopedic and sports medicine small animal veterinarian, my primary focus is on returning patients to full function as quickly and safely as possible using innovative evidence-based approaches. I look forward to working with PetVivo and their Spyrng with Osteocushion Technology to deliver long-term relief from the pain associated with osteoarthritis, by addressing the underlying structural issues, so that we can restore mobility and improve patient joint function over a longer period,” Sherman O. Canapp Jr., DVM, MS, CCRT, DACVS (SA), DACVSMR, president and CEO of OBI, said in a news release.¹

Alongside Sherman O. Canapp, Debra Canapp, DVM, CCRT, CVA, DACVSMR, will form part of OBI’s collaboration with PetVivo, as she has experience in rehabilitation and diagnostic musculoskeletal ultrasound from Veterinary Orthopedic & Sports Medicine Group.¹

“We chose to team with OBI because they are consistently on the frontline of new medical technologies,” said John Lai, PetVivo president and CEO, in the release.¹ “Sherman and Debra bring impressive knowledge and experience, particularly from their work in helping to develop new medical products that focus on the physical health of small animals and arthritis interventions.”

“This makes their team a great fit with furthering our clinical trials and expanding the market adoption of Spryng,” continued Lai, in the release.¹ “They will help us build product awareness and accelerate the growth and the expansion of our market reach across the US.”

References

1. PetVivo teams with Orthobiologic Innovations for clincial research and product commercialization. News release. PetVivo Holdings, Inc. August 27, 2024. Accessed September 13, 2024. [email]
2. Harari J. Degenerative arthritis in dogs and cats. Merck Veterinary Manual. November 2020. Accessed September 13, 2024. https://www.merckvetmanual.com/musculoskeletal-system/arthropathies-and-related-disorders-in-small-animals/degenerative-arthritis-in-dogs-and-cats
3. Spryng with OsteoCushion Technology. PetVivo , Inc. Accessed September 13, 2024. https://www.sprynghealth.com