Paul Bloom, DVM, DACVD, DABVP

Articles by Paul Bloom, DVM, DACVD, DABVP

The diagnosis of ANY skin disease is based on detailed history taking, clinical findings (identification of primary lesions, distribution of lesions), laboratory testing and therapeutic trials. For autoimmune skin diseases (AISD) the most beneficial laboratory procedure is histopathologic evaluation.

Vasculitis is characterized by an aberrant immune response directed toward blood vessels. Histologically there is an inflammatory response involving and destroying blood vessels leading to ischemic changes (see histopathology). A vasculopathy is a disease process in which tissue changes are consistent with ischemia but histologically vasculitis can't be identified.

Itraconazole (Sporonax ?-Janssen Pharmaceuticals- 100 capsules and 10 mg/ml oral solution)) is a member of the azole family of antifungal agents. Imidazoles (Imidazole family (thiabendazole, clotrimazole, ketaconazole, miconazole and enilconazole) and triazoles (itraconazole and fluconazole) make up this family of drugs.

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Protocols are useful in helping to diagnose and treated many different disorders. Part of any good protocol should be a minimum data base (MDB). In addition to signalment, history, etc in veterinary dermatology laboratory testing should be a component of this data base.

Malassezia is a genus of lipophilic yeast found as a commensal of the skin and mucosal surfaces that may cause skin disease in a variety of mammalian species. In normal dogs these organisms are present in very small numbers on the skin (fold areas-lip, vulvar, axillae, interdigital), oral and anal mucosal surfaces, in the ear canals and anal sacs. In contrast to Candida, MD is not associated w/recent antibiotic administration, in fact, there appears to be a symbiotic relationship between the surface staphylococcal organisms and the yeast.

The diagnosis of ANY skin disease is based on detailed history taking, clinical findings (identification of primary lesions, distribution of lesions), laboratory testing and therapeutic trials. For autoimmune skin diseases (AISD) the most beneficial laboratory procedure is histopathologic evaluation.

Alopecia in the dog is a common clinical finding. It is most commonly associated with pruritus due to allergic skin disease. There are also many causes of nonpruritic alopecia. Since the skin and hair can only "react" in a limited manner regardless of the triggering event, signalment, history (hx), physical exam (PE) and laboratory testing (eg skin scrapings, skin biopsies, fungal cultures, endocrine testing, intradermal testing, etc) all may be needed to help determine the underlying cause.