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This presentation attempts to summarize some of the major concerns in resistance development along with key articles explaining relevance, epidemiology, and prevalence. It is not intended to be an exhaustive review of the literature and the interested practitioner should use the cited literature herein as a basis for continued, extended reading.

The capacity to experience pain is considered to have a protective role by eliciting behavioral responses aimed at reducing further tissue damage and enhance wound healing. However, persistent pain syndromes offer no biological advantage and are associated with suffering and distress.

The science of how drugs work on the body (or the microorganism or parasite) is pharmacodymanics (its counterpart being pharmacokinetics, how the body works on the drug). In this section, the basic concepts of drug concentration and drug action are followed by a review of the mechanisms of action of the major drug groups used in food animal practice including NSAIDs, glucocorticoids, reproductive drugs, antimicrobials, and parasiticides.

Fluid therapy is one of the most important aspects of patient management in veterinary medicine. It is however, important to realize that fluid therapy is a supportive measure and the underlying disease process that lead to aberrations in water, electrolyte and acid-base status must be identified and treated.

Productivity for beef cattle herds has been shown to be increased when a high percentage of heifers become pregnant early in the first breeding season. A producer's heifer selection and development program should result in most heifers in the replacement pool reaching puberty at least 42 days prior to the start of breeding because the conception success to first service is lower on the puberal estrus compared to the third estrus.

Many veterinarians express frustration when trying to provide their clients with the best advice on which diagnostic tests to recommend for purchased cattle or the resident herd. The goal is to screen apparently healthy cattle to identify carriers of infectious disease that could cause reproductive losses and other health problems in the herd.

Acute renal failure may be defined as an abrupt reduction in renal function resulting in accumulation of nitrogenous waste products and dysregulation of water, electrolyte, and acid base balance. Differentiating acute from chronic kidney disease is important for both therapeutic and prognostic reasons.

Enterotoxemia is characterized by proliferation of and exotoxin production by Clostridium perfringens in the lumen of the gastrointestinal tract. Although limited tissue invasion by the causative organism does occur, most local and systemic lesions result from the local and systemic effects of potent exotoxins produced by certain genotypes of this bacteria.

Maintenance of the physical and mental well being of animals within the shelter is a very important part of the stated mission for most sheltering organizations, yet surprisingly often stress reduction and enrichment to ensure good behavioral health is considered a luxury rather than part of basic care. An animal's behavioral health is a result of their genetic background, their learned behavior patterns as a result of previous experiences, and their environment.

Shelter statistics may not seem like the most exciting topic to consider, but is in my opinion one of the most important tools you have in your belt when it comes to shelter animal health.

These proceedings present data related to the question of how long to wait after administering a single injection antimicrobial before applying success/failure criteria. More accurately, we will evaluate success/failure and mortality data based on administering a uniform regimen and then waiting different periods before applying success/failure criteria, and the animal subsequently being eligible for further therapy.

Small ruminants constitute a rewarding component of a mixed or rural veterinary practice. In such practice scenarios, certain common medical disorders of small ruminants may be encountered on a fairly regular basis. The following cases are valuable teaching cases because they involve differential diagnoses that are commonly encountered in small ruminant practice.

Developing herd health programs for cow-calf operations can be time consuming but rewarding for both the producer and the veterinarian if done appropriately. However, many producers think of a herd health program as only a vaccine program. Interestingly, the vaccination schedule and the vaccines that will be used constitute the smallest portion of a true herd health program.

This checklist serves as a starting point for evaluating your applications of antimicrobials in food animals.

Increased population density leads to animal STRESS, a greater risk of disease introduction, higher contact rate, reduced air quality, exhausted resources, staff stress and commonly compromises in housing and husbandry. Unfortunately, crowding in shelters is not uncommon, either due to insufficient facilities, or a well-intended attempt to decrease euthanasia by housing more animals.

Antimicrobial efficacy in cattle can be evaluated through clinical studies including a negative control group. To be included here, the study must have specified that the subjects were randomized, the evaluators were masked to treatment, and that statistical analysis was applied. Much of the data were compiled from Food and Drug Administration Freedom of Information (FOI) summaries for veterinary drug approvals.

For those of us who are tolerating bawling calves for four or five days in a row, tolerating buller rates of over a half a percent, please listen and see if some of these things might be helpful.

Oral exposure to toxicants among small animals (pets) is the most common. Biological activities are graded, and, are based on toxicants reaching their sites of action (effectors) in biological system at a sufficient concentration and duration. Intensity of a biological effect is dose related. Basic pharmacokinetic/toxicokinetic principles of toxicants become essential in addressing toxicity. Toxicant concentrations at effector sites are based on absorption, distribution, metabolism, and excretion of individual toxicants.

In most cases, we administer drugs at a different site than we want to drug to act. Understanding how drugs get to their site of action and how long they stay there is essential to making therapeutic decisions about which drug, what route, how much, how often, and for how long.

Chronic kidney disease (CKD) is a common clinical diagnosis in middle-aged to geriatric cats and dogs that may significantly affect the quality of life of both the patients and their owners. Although "old age" is not a disease, it is a time when many diseases are more likely to occur, often concurrently.

We have talked about supervision and finding treatment failures and conditions that have low odds of successful treatment in an efficient manner that is cost efficient for the dairy, good welfare for the cow and work we'd like to do. These are hollow words unless it can be delivered to the cows in need on a timely basis.

Trichomoniasis, or "trich," is a disease that can cause devastating reductions in the percentage of cows exposed to a bull that successfully calve. The disease is caused by a protozoan parasite, Tritrichomonas foetus and the organism is transmitted by the act of mating.

Pathogens differ in their virulence, contagiousness, and their modes of transmission. These differences exist not only between pathogens, but for virulence and contagiousness, can also differ between strains of the same species of pathogen.

Incidence of feedlot lameness varies by feedlot from .03% to 2.3% of cattle inventory on a health data base that includes 5,540,000 cattle in feedlots that vary in capacity from 5000 to 80,000 head. The average lameness incidence is .51%.

Anemia is a common clinical finding in both human and veterinary patients with chronic kidney disease (CKD). Anemia has been reported as a clinical complication in 80-90% of human dialysis patients, and in 32-65% of cats with CKD.

Agents (physical, chemical or biological) designed to kill pests that interfere with the comfort, health or economic wellbeing of man. Accompanying their beneficial effects, illnesses and deaths in man and animal alike, have been reported. Recorded use of compounds in the control of pests goes back to 1000 BC, when sulfur was used for such purpose. Since then their have been continued development of more effective and safe pesticides. Currently in use today are > 600 pesticides, constituting 15,000 compounds in 3,500 formulations.

Pets' eating and grooming habits, species inherent sensitivities to certain chemical/foods, and owners' attitudes are helpful in preventing accidental exposures. Similar hand-to-mouth behavior observed in children is the expected with pets. All precautions – properly store all hazardous chemicals, personal human medication, read medication labels, and know the need for, and seek immediate veterinary care - should be taken in preventing access of pet to hazardous substances.

A lingering human impression that most synthetic chemicals/compounds are unsafe and those of natural origin are safe remains un-substantiated. Of an estimated 30,000 plant species (wild and cultivated) found in North America, approximately 700 species have been reported toxic to animals. These plants are toxic on account of chemicals found in them, which are toxic to animals on ingestions. These components (alkaloids, glycosides, phenols, phyto estrogens, resins etc.) are structurally and functionally diverse.

One can usually find many sources of information about drugs: FDA website, drug company websites and technical reports, VIN, journals, trade magazines, and so on. The important skill required of veterinarians is to assess that information to determine its usefulness in your daily practice.

This morning we're going to talk about our least favorite topic – sick cattle. Sick cattle are not fun to deal with, but we're always going to have some of them. I want you to understand that our philosophy should be to invest time at strategic points of the production cycle to reduce time spent at hospitals.